Record-breaking Ramos left out by Spain
Spain to lift the trophy for a fourth time, will go into next month's finals without Ramos, the national team skipper and record cap holder.
However, Enrique has found a place for Manchester City centre-back Eric Garcia, who has made just one Premier League start this season.
There are no Real players at all in the squad as Ramos's teammates Dani Carvajal and Nacho have also been omitted by Enrique, who insisted that form and fitness were the only things on his mind when he named his 24-man squad.
Ramos is Spain's record all-time appearance maker with 180 caps and is their eighth-highest goalscorer, but he has had a campaign riddled with injuries, making only 21 appearances in all competitions for Real, including 15 La Liga games.
He underwent knee surgery in January and missed Real's final game of the season – Saturday's 2-1 win over Villarreal – after suffering another setback.
The 35-year-old defender had started nine out of ten Euro 2020 qualifiers for La Roja, who will go to a major finals without a Real Madrid player for the first time in their history.
Enrique, who played for Real Madrid before moving to Barcelona who he later coached, said he told Ramos on the phone on Sunday night that he was not in the squad.
"It was a difficult and tough decision but the best thing for the team," Enrique told reporters. "I would have liked Ramos to be in the squad but did not think it was viable because he has practically been unable to compete."